Comprehensive comparison between Sildenafil/Tadalafil

David Banks
Authored by David Banks
Posted Wednesday, April 14, 2021 - 6:00pm

Sildenafil is the active ingredient in Viagra and tadalafil is the active ingredient in Cialis. You can read this article if you are looking for a brief comparison. Here we look at the medical effectiveness of both of these drugs in context to each other. We are not saying that any drug is better or more effective than the other because each person will respond to both of these drugs differently.


Sildenafil, the active ingredient in Viagra, is a PDE-5 inhibitor. Tadalafil, the active ingredient in Cialis, is also a PDE-5 inhibitor. The composition of both of these drugs helps users inhibit PDE-5. PDE-5 can be described as the enzyme that persuades the penis to become flaccid. 

PDE-5 is present in the lining of the penis as well as the lungs. Both of these chemicals do not guarantee an erection but they can help men get and maintain an erection. The chemicals have a success rate of above 80%, even with the disclaimer because there are many long years of research behind these chemicals. 

Sildenafil and Tadalafil were initially patented by Viagra and Cialis but that restriction no longer exists. There are many more affordable versions of the same drug available on the market that have the same effect if not better. 

Activation Time and Longevity

Tadalafil and Sildenafil are some of the most popular erectile dysfunction drugs but there are subtle differences between the two. The two most important factors to consider for people, young and old, taking this medication is how long it takes to work and how long it will stay in my system. Activation time is referred to as the time it takes for the chemical to get absorbed into the system after swallowing the tablet. The whole experience of using the medication can be ruined by prolonged activation times for your partner who is in the mood now. 

Longevity refers to the amount of time it takes for the concentration of the chemical to be halved in the system in comparison to first swallowing the drug. A longer duration usually means that there are long-lasting impacts of the drug. A shorter duration means that the drug will reach peak efficiency relatively quickly but it will also be cleared from your metabolism in a short time.


Sildenafil gets activated in the system anywhere between 45 to 60 minutes. In very rare cases, with older adults or people with a slow metabolism, it can take longer than that. This means that the drug is relatively fast-acting for people looking for uninhibited straightforward sex. A person can use the drug for a one-time session that happens roughly 45 minutes after ingesting the drug. 

Sildenafil might be your choice if you are looking for a temporary solution for erectile dysfunction.


Tadalafil takes about 60 to 90 minutes to activate and there are rare cases that some people might take longer. Tadalafil has a half-life of almost 18 hours. This is why it is also sometimes referred to as the weekender pill. That’s right, its effects can last for almost an entire weekend. 

Tadalafil is a more permanent solution to erectile dysfunction problems because it will come into play whenever you are in the mood. 


Always consult a physician first to see if any of these medications counteract your current treatment plan. A physician understands the advantages and disadvantages of the drugs as well as the demands of your physical condition.


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